Glossary entry (derived from question below)
Spanish term or phrase:
necrosis de predominio centrozonal
English translation:
predominantly centrilobular necrosis
Added to glossary by
Joseph Tein
Jun 20, 2010 06:03
13 yrs ago
5 viewers *
Spanish term
United States
Multilingual. Very careful & precise.
Native in: English 
Works in: Spanish to English, Italian to English
necrosis de predominio centrozonal
Spanish to English
Medical
Medical (general)
liver disease - toxic hepatitis
"La biopsia hepática no es necesaria para el diagnóstico, pero la presencia de **necrosis de predominio centrozonal** y ... apoyan la sospecha clínica."
It's really the word "centrozonal" that I need help with. I find it used in a number of references in English, but the ones I look at seem to be translated from other languages or written by non-native English speakers.
Is "centrozonal" an acceptable and correct English translation for the Spanish, or is there another term that is more widely used in English?
Thanks.
It's really the word "centrozonal" that I need help with. I find it used in a number of references in English, but the ones I look at seem to be translated from other languages or written by non-native English speakers.
Is "centrozonal" an acceptable and correct English translation for the Spanish, or is there another term that is more widely used in English?
Thanks.
Proposed translations
(English)
| 4 +4 | predominant zone III/centrilobular necrosis |
Panagiotis Andrias (X)
|
| 4 +2 | predominant centrizonal necrosis |
casper (X)
|
| 4 +1 | necrosis predominantly in the central area/zone |
David Brown
|
| 4 | predominantly centrozonal necrosis |
Constantinos Faridis (X)
|
| 4 | centrozonal necrosis |
Pedro P Barrero MD
|
Proposed translations
+4
1 hr
Selected
predominant zone III/centrilobular necrosis
-Hi, Joseph...
-or "zone 3 necrosis"...
- according to Rappaport' s zonal acinar model/concept...
-would definetely go for zone III/zone 3 and avoid centrizonal... much more clear for all physicians worldwide i think...
fig. 2.13 and 2.15 here...
http://books.google.gr/books?id=oL6d9KuVqLQC&lpg=PA27&ots=gT...
http://books.google.gr/books?id=08a3FiePGGQC&lpg=PA13&ots=rW...
http://books.google.gr/books?id=cvJuLqBxGUcC&lpg=PA413&ots=J...
Structural and functional liver units
Classic hepatic lobule
central vein forms the center of the classic lobule with portal triads at its periphery blood flows from the periphery to the center of the lobule while bile flows from the center to the periphery of the lobule
Portal lobule
portal triad forms the center of the portal lobule with the central vein at its periphery blood flows from the center to the periphery while bile flows from the periphery to the center
Hepatic acini (zones 1, 2 and 3) of Rappaport
hepatic acinus represents a liver lobule that is divided into 3 regions based on their proximity to the distributing veins
Zone I
cells closest to the vessels (portal triad) and 1st to be affected by incoming blood
Zone II
cells which are 2nd to respond to blood (in between portal triad and central vein)
Zone III
cells near the central vein which see blood that has already been altered by cells in zones I and II
http://d3jonline.tripod.com/21-Gastrointestinal/Histology_of...
The two-dimensional microarchitecture of the liver can be viewed from multiple different perspectives.
Name / Shape
classical lobule / hexagonal; divided into concentric centrilobular, midzonal, periportal parts
portal lobule / triangular; centered around a portal triad
acinus / elliptical or diamond-shaped; divided into zone I (periportal), zone II (transition zone), and zone III (centrilobular)
http://en.wikipedia.org/wiki/Hepatic_lobule
http://www.siumed.edu/~dking2/erg/liver.htm.
http://www.meddean.luc.edu/lumen/MedEd/orfpath/acifrm.htm.
La grasa se acumula en la zona 3 (centrozonal) y en la 2 (mediozonal).
http://www.scribd.com/doc/7219603/Cirrosis-Hepatica.
“Necrosis centrozonal”, cuando la necrosis se produce alrededor de la vena central
hera.ugr.es/tesisugr/17663544.pdf -
http://www.google.gr/search?hl=el&lr=lang_en&as_qdr=all&tbs=...
http://www.google.gr/search?hl=el&lr=lang_en&as_qdr=all&tbs=...
http://www.google.gr/search?hl=el&lr=lang_en&as_qdr=all&tbs=...
http://www.google.gr/search?hl=el&lr=lang_en&as_qdr=all&tbs=...
The terms centrilobular or zone 3 necrosis refer to injury that surrounds the central vein.
http://books.google.gr/books?id=cvJuLqBxGUcC&lpg=PA413&ots=J...
http://www.google.gr/search?q=hepatic "centrizonal" zone 3&b...
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Note added at 1 ώρα (2010-06-20 07:44:26 GMT)
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http://www.google.gr/search?hl=el&lr=lang_en&as_qdr=all&tbs=...
http://www.google.gr/search?hl=el&lr=lang_en&as_qdr=all&tbs=...
http://www.google.gr/search?hl=el&lr=lang_en&as_qdr=all&tbs=...
--------------------------------------------------
Note added at 7 ώρες (2010-06-20 13:41:59 GMT)
--------------------------------------------------
obvious that the issue here is not the predominio part... it' s all about zone 3 necrosis...
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Note added at 13 ώρες (2010-06-20 19:57:26 GMT)
--------------------------------------------------
Sì, Joseph. centrilobular=centrizonal=zone 3. Eccoti la conferma:
http://www.google.com/search?hl=el&lr=lang_en&tbs=bks:1,bkv:...
http://www.google.com/search?hl=el&lr=lang_en&tbs=bks:1,bkv:...
The area around the CV is called centrizonal or centrilobular area
http://www.icmr.nic.in/ijmr/2009/may/0515.pdf.
Centrizonal necrosis (centrilobular necrosis) refers to JFSS 1989; 29(3): 185-189 187 necrotic central hepatocytes with haemorrhagic centrilobular zone [8]. ...
linkinghub.elsevier.com/retrieve/pii/S0015736889732461
http://books.google.com/books?id=08a3FiePGGQC&lpg=PA20&ots=r...
Comparison of Lobular and Acinar TerminologiesFigure by MIT OCW.
Lobular - Acinar
~ Central; centrilobular; centrizonal - Perivenular; acinar zone 3
~ Mid-zonal - Acinar zone 2
~ Peripheral; periportal - Periportal; acinar zone 1
http://ocw.mit.edu/courses/biological-engineering/20-450-mol...
-or "zone 3 necrosis"...
- according to Rappaport' s zonal acinar model/concept...
-would definetely go for zone III/zone 3 and avoid centrizonal... much more clear for all physicians worldwide i think...
fig. 2.13 and 2.15 here...
http://books.google.gr/books?id=oL6d9KuVqLQC&lpg=PA27&ots=gT...
http://books.google.gr/books?id=08a3FiePGGQC&lpg=PA13&ots=rW...
http://books.google.gr/books?id=cvJuLqBxGUcC&lpg=PA413&ots=J...
Structural and functional liver units
Classic hepatic lobule
central vein forms the center of the classic lobule with portal triads at its periphery blood flows from the periphery to the center of the lobule while bile flows from the center to the periphery of the lobule
Portal lobule
portal triad forms the center of the portal lobule with the central vein at its periphery blood flows from the center to the periphery while bile flows from the periphery to the center
Hepatic acini (zones 1, 2 and 3) of Rappaport
hepatic acinus represents a liver lobule that is divided into 3 regions based on their proximity to the distributing veins
Zone I
cells closest to the vessels (portal triad) and 1st to be affected by incoming blood
Zone II
cells which are 2nd to respond to blood (in between portal triad and central vein)
Zone III
cells near the central vein which see blood that has already been altered by cells in zones I and II
http://d3jonline.tripod.com/21-Gastrointestinal/Histology_of...
The two-dimensional microarchitecture of the liver can be viewed from multiple different perspectives.
Name / Shape
classical lobule / hexagonal; divided into concentric centrilobular, midzonal, periportal parts
portal lobule / triangular; centered around a portal triad
acinus / elliptical or diamond-shaped; divided into zone I (periportal), zone II (transition zone), and zone III (centrilobular)
http://en.wikipedia.org/wiki/Hepatic_lobule
http://www.siumed.edu/~dking2/erg/liver.htm.
http://www.meddean.luc.edu/lumen/MedEd/orfpath/acifrm.htm.
La grasa se acumula en la zona 3 (centrozonal) y en la 2 (mediozonal).
http://www.scribd.com/doc/7219603/Cirrosis-Hepatica.
“Necrosis centrozonal”, cuando la necrosis se produce alrededor de la vena central
hera.ugr.es/tesisugr/17663544.pdf -
http://www.google.gr/search?hl=el&lr=lang_en&as_qdr=all&tbs=...
http://www.google.gr/search?hl=el&lr=lang_en&as_qdr=all&tbs=...
http://www.google.gr/search?hl=el&lr=lang_en&as_qdr=all&tbs=...
http://www.google.gr/search?hl=el&lr=lang_en&as_qdr=all&tbs=...
The terms centrilobular or zone 3 necrosis refer to injury that surrounds the central vein.
http://books.google.gr/books?id=cvJuLqBxGUcC&lpg=PA413&ots=J...
http://www.google.gr/search?q=hepatic "centrizonal" zone 3&b...
--------------------------------------------------
Note added at 1 ώρα (2010-06-20 07:44:26 GMT)
--------------------------------------------------
http://www.google.gr/search?hl=el&lr=lang_en&as_qdr=all&tbs=...
http://www.google.gr/search?hl=el&lr=lang_en&as_qdr=all&tbs=...
http://www.google.gr/search?hl=el&lr=lang_en&as_qdr=all&tbs=...
--------------------------------------------------
Note added at 7 ώρες (2010-06-20 13:41:59 GMT)
--------------------------------------------------
obvious that the issue here is not the predominio part... it' s all about zone 3 necrosis...
--------------------------------------------------
Note added at 13 ώρες (2010-06-20 19:57:26 GMT)
--------------------------------------------------
Sì, Joseph. centrilobular=centrizonal=zone 3. Eccoti la conferma:
http://www.google.com/search?hl=el&lr=lang_en&tbs=bks:1,bkv:...
http://www.google.com/search?hl=el&lr=lang_en&tbs=bks:1,bkv:...
The area around the CV is called centrizonal or centrilobular area
http://www.icmr.nic.in/ijmr/2009/may/0515.pdf.
Centrizonal necrosis (centrilobular necrosis) refers to JFSS 1989; 29(3): 185-189 187 necrotic central hepatocytes with haemorrhagic centrilobular zone [8]. ...
linkinghub.elsevier.com/retrieve/pii/S0015736889732461
http://books.google.com/books?id=08a3FiePGGQC&lpg=PA20&ots=r...
Comparison of Lobular and Acinar TerminologiesFigure by MIT OCW.
Lobular - Acinar
~ Central; centrilobular; centrizonal - Perivenular; acinar zone 3
~ Mid-zonal - Acinar zone 2
~ Peripheral; periportal - Periportal; acinar zone 1
http://ocw.mit.edu/courses/biological-engineering/20-450-mol...
Note from asker:
| Gracias Παναγιώτης :) |
| Ciao Panagiotis ... una domanda: is "centrilobular" equivalent to "centrizonal"? I found "centrilobular necrosis" much more frequently in my online search, but I didn't know if it means the same thing. Ευχαριστώ! |
Peer comment(s):
| agree |
ARS54
3 hrs
|
|
Thank you, dear AR...
|
|
| agree |
Anne Schulz
9 hrs
|
|
Thank you, Anne.
|
|
| agree |
Rita Tepper
13 hrs
|
|
Thank you, Rita.
|
|
| agree |
Emma Goldsmith
: Following your confirmation that centrilobular is the same as centrizonal, I think this is the best answer.
3 days 1 hr
|
|
Thank you, Emma.
|
4 KudoZ points awarded for this answer.
Comment: "Ciao Panagiotis and thank you again for your help. With your suggestions and everyone else's support, I decided that 'centrilobular' is the best solution here."
17 mins
predominantly centrozonal necrosis
A liver biopsy specimen showed predominantly centrozonal necrosis and inflammatory eosinophilic ... A liver biopsy showed marked centrozonal necrosis. ...
www.journals.uchicago.edu ›
www.journals.uchicago.edu ›
+2
27 mins
predominant centrizonal necrosis
It's centrizonal in English, AFAIK.
As a general rule, direct forms of liver injury tend to cause predominant centrizonal necrosis...
http://tinyurl.com/32nolkn
As a general rule, direct forms of liver injury tend to cause predominant centrizonal necrosis...
http://tinyurl.com/32nolkn
Peer comment(s):
| agree |
Yasser El Helw
: Centrizonal is OK.
1 hr
|
|
Thank you for confirming this, Yasser El Helw
|
|
| agree |
liz askew
: I am no medic, but as a medical linguist this is how I would translate it, FWIW. [after further research:)] although I might use "predominantly" as an adverb.
3 hrs
|
|
Thank you, liz askew. And yes, you have a point: 'predominantly' looks much better.
|
+1
1 day 14 mins
necrosis predominantly in the central area/zone
..being old fashioned....
traditional gross anatomy divided the liver into four lobes based on surface features. ... The central area where the common bile duct, hepatic portal vein, ...
en.wikipedia.org/wiki/Liver - hace 13 minutos - En caché
administration of carbon tetrachloride is localized predominantly in the central zone of the liver lobule (for references see Aterman, 1954). ...
www.ncbi.nlm.nih.gov/pmc/articles/.../pdf/bripharmchem00066...
After 48 hr, coagulation necrosis of liver cells in the central zone became ... Predominant balloon-like swelling of the cells at the middle zone of the ...
linkinghub.elsevier.com/retrieve/pii/0026286269900168
Periportal, predominantly neutro- philic infiltrate, Pseudoxanthomas. .... sistent central zone necrosis. 116. Mild portal inflammation ...
deepblue.lib.umich.edu/bitstream/2027.42/.../1840160312_ftp.pdf - Similares
traditional gross anatomy divided the liver into four lobes based on surface features. ... The central area where the common bile duct, hepatic portal vein, ...
en.wikipedia.org/wiki/Liver - hace 13 minutos - En caché
administration of carbon tetrachloride is localized predominantly in the central zone of the liver lobule (for references see Aterman, 1954). ...
www.ncbi.nlm.nih.gov/pmc/articles/.../pdf/bripharmchem00066...
After 48 hr, coagulation necrosis of liver cells in the central zone became ... Predominant balloon-like swelling of the cells at the middle zone of the ...
linkinghub.elsevier.com/retrieve/pii/0026286269900168
Periportal, predominantly neutro- philic infiltrate, Pseudoxanthomas. .... sistent central zone necrosis. 116. Mild portal inflammation ...
deepblue.lib.umich.edu/bitstream/2027.42/.../1840160312_ftp.pdf - Similares
1 day 1 hr
Pedro P Barrero MD
Spain
Spain
Native in Spanish
&
English
Specializes in field
Spain
Medical Translations
Native in: Spanish , English
Works in: English to Spanish, French to Spanish, Spanish to English, and 1 more.
centrozonal necrosis
Necrosis predominantly affecting or limited to a defined anatomical area.
Reference comments
11 hrs
Reference:
http://webcache.googleusercontent.com/search?q=cache:8JdVaiv...
Aunque la biopsia hepática no es usualmente diagnóstica de hepatotoxicidad, y principalmente se indica para excluir otras causas de hepatopatía o con fines pronósticos, la presencia ocasional de necrosis de predominio centrozonal (área de mayor actividad del citocromo P-450), infiltrado
eosinofílico y granulomas apoyan la sospecha clínica.
MERCK
The fact that the cytochrome P450 system centrizonal in location and the liver autopsy showed centrizonal necrosis in this case was the base of the proposed ...
pt.wkhealth.com/pt/re/merck/fulltext.00006565-200508000-00010.htm;...
Hepatotoxicity: the adverse effects of drugs and other chemicals ... - Google Books Result
Hyman J. Zimmerman - 1999 - Medical - 789 pages
... creatine kinase CPZ: Chlorpromazine CV: Central vein (efferent venule) CYP: Cytochrome P450 Cyt: Cytochrome CZ: Centrizonal (acinar zone 3) 2,4-D: 2 ...
books.google.co.uk/books?isbn=0781719526...
Inactivation of the Hepatic Cytochrome P450 System by Conditional ...
by CJ Henderson - 2003 - Cited by 88 - Related articles
Cytochrome P450 (CYP) monooxygenases catalyze the oxidation of a large number of ..... Otherwise, hepatocytes in both the centrizonal and periportal regions ...
www.jbc.org/content/278/15/13480.full
--------------------------------------------------
Note added at 11 hrs (2010-06-20 17:52:13 GMT)
--------------------------------------------------
MacSween's pathology of the liver - Google Books Result
Roderick N. M. MacSween, Alastair D. Burt ... - 2007 - Medical - 973 pages
Superficial Table 1.1 Lobular Comparison of lobular and ac •terminologies Central; centrilobular; centrizonal Acinar Perivenular; acinar zone 3 Mid-zonal ...
books.google.co.uk/books?isbn=0443100128...
--------------------------------------------------
Note added at 11 hrs (2010-06-20 17:53:48 GMT)
--------------------------------------------------
I do not know whether "centrilobular" and "centrizonal" are synonyms and for that reason I would go for the literal translation of the Spanish source text. i.e. "centrizonal".
Therein lies the dilemma of the medical linguist, rather than a medically-trained linguist!!
--------------------------------------------------
Note added at 11 hrs (2010-06-20 17:54:59 GMT)
--------------------------------------------------
it would appear the liver has 4 lobes in any case, just to complicate matters:)
Human Liver Diagram - Digestive System
The liver has two major lobes and two minor lobes. Anteriorly, the right lobe is separated from the smaller left lobe by the falciform ligament. ...
www.innerbody.com/image/dige07.html - Cached - Similar
Aunque la biopsia hepática no es usualmente diagnóstica de hepatotoxicidad, y principalmente se indica para excluir otras causas de hepatopatía o con fines pronósticos, la presencia ocasional de necrosis de predominio centrozonal (área de mayor actividad del citocromo P-450), infiltrado
eosinofílico y granulomas apoyan la sospecha clínica.
MERCK
The fact that the cytochrome P450 system centrizonal in location and the liver autopsy showed centrizonal necrosis in this case was the base of the proposed ...
pt.wkhealth.com/pt/re/merck/fulltext.00006565-200508000-00010.htm;...
Hepatotoxicity: the adverse effects of drugs and other chemicals ... - Google Books Result
Hyman J. Zimmerman - 1999 - Medical - 789 pages
... creatine kinase CPZ: Chlorpromazine CV: Central vein (efferent venule) CYP: Cytochrome P450 Cyt: Cytochrome CZ: Centrizonal (acinar zone 3) 2,4-D: 2 ...
books.google.co.uk/books?isbn=0781719526...
Inactivation of the Hepatic Cytochrome P450 System by Conditional ...
by CJ Henderson - 2003 - Cited by 88 - Related articles
Cytochrome P450 (CYP) monooxygenases catalyze the oxidation of a large number of ..... Otherwise, hepatocytes in both the centrizonal and periportal regions ...
www.jbc.org/content/278/15/13480.full
--------------------------------------------------
Note added at 11 hrs (2010-06-20 17:52:13 GMT)
--------------------------------------------------
MacSween's pathology of the liver - Google Books Result
Roderick N. M. MacSween, Alastair D. Burt ... - 2007 - Medical - 973 pages
Superficial Table 1.1 Lobular Comparison of lobular and ac •terminologies Central; centrilobular; centrizonal Acinar Perivenular; acinar zone 3 Mid-zonal ...
books.google.co.uk/books?isbn=0443100128...
--------------------------------------------------
Note added at 11 hrs (2010-06-20 17:53:48 GMT)
--------------------------------------------------
I do not know whether "centrilobular" and "centrizonal" are synonyms and for that reason I would go for the literal translation of the Spanish source text. i.e. "centrizonal".
Therein lies the dilemma of the medical linguist, rather than a medically-trained linguist!!
--------------------------------------------------
Note added at 11 hrs (2010-06-20 17:54:59 GMT)
--------------------------------------------------
it would appear the liver has 4 lobes in any case, just to complicate matters:)
Human Liver Diagram - Digestive System
The liver has two major lobes and two minor lobes. Anteriorly, the right lobe is separated from the smaller left lobe by the falciform ligament. ...
www.innerbody.com/image/dige07.html - Cached - Similar
Peer comments on this reference comment:
| neutral |
Panagiotis Andrias (X)
: Hi. Liz. Not a case of liver lobes at all... Just a matter of lobule (hepatic or portal one)... Have a nice day...
3 days 11 hrs
|
14 hrs
Rita Tepper
Native in Spanish
Specializes in field
Reliable translations reliable physician
Native in: Spanish 
Works in: Spanish to English, English to Spanish
Related KudoZ points
:
418
Reference:
periacinar/centrilobular necrosis
I would definitely not use centrizonal necrosis.
The most common pattern is periacinar necrosis (also called centrilobular necrosis). It is the pattern produced by many toxic chemicals and by several adeno ...
books.google.com.ar/books?isbn=0521548136...
centrilobular
pertaining to the central portion of a lobule.
centrilobular necrosis
necrosis restricted to the hepatocytes immediately surrounding the central venule. Called also periacinar necrosis.
http://medical-dictionary.thefreedictionary.com/centrilobula...
The most common pattern is periacinar necrosis (also called centrilobular necrosis). It is the pattern produced by many toxic chemicals and by several adeno ...
books.google.com.ar/books?isbn=0521548136...
centrilobular
pertaining to the central portion of a lobule.
centrilobular necrosis
necrosis restricted to the hepatocytes immediately surrounding the central venule. Called also periacinar necrosis.
http://medical-dictionary.thefreedictionary.com/centrilobula...
Note from asker:
| Hola Rita, saludos y gracias por tu apoyo. |
Discussion