Glossary entry

English term or phrase:

AST

English answer:

aspartate aminotransferase

Added to glossary by Veronica Prpic Uhing
Nov 27, 2004 17:38
19 yrs ago
2 viewers *
English term

AST

English Other Chemistry; Chem Sci/Eng
aspartate aminotransferase (AST)
aspartate transaminase (AST)

what is the difference? are they the same thing? is transaminase the new name - i.e. aminotransferase formerly known as transaminase (see eurodicautom)

how fundamental is it to use the new name (if this is the case).

thanks

Discussion

Veronica Prpic Uhing Nov 27, 2004:
It must be -
ALT reaction is -- L-alanine + 2-oxoglutarate = pyruvate + L-glutamate
AST reaction is --- L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

Non-ProZ.com Nov 27, 2004:
thank you VPUHING so why does it say ALT and not AST?
it should be Asparate Aminotransferase (AST)
Should I assume it's a mistake? I guess...
Veronica Prpic Uhing Nov 27, 2004:
ALT is alanine aminotransferase - Systematic name: L-alanine:2-oxoglutarate aminotransferase --- by IUBMB -- EC 2.6.1.2
Non-ProZ.com Nov 27, 2004:
Thanks, I may have to ask the client i.e. I am making additions to a translation and was surprised to find transaminase (in target language, in English it is updated, aminotransferase) on the other hand I have been asked to maintain consistency with the previous translation. So maybe I will suggest the change � personally I would prefer to change it ...

any thoughts on: Asparate Aminotransferase (ALT)(in English)
copyrighter was tired?
am I missing out on something?
Non-ProZ.com Nov 27, 2004:
November 2004 is it OK to use the term aspartate transaminase - or should I update to aspartate aminotransferase?

Responses

2 hrs
Selected

Info

Info
According to IUBMB (International Union of Biochemistry and Molecular Biology)enzyme nomenclature
AST enzyme is classified as EC 2.6.1.1

Common name is: aspartate transaminase

Systematic name: L-aspartate:2-oxoglutarate aminotransferase

Other names include also - aspartate aminotransferase

Since aminotransferase is an enzyme that catalyzes the transfer of an amino group from a donor molecule to a recipient molecule
aspartate aminotransferase is more appropriate unless you need systematic name
http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/6/1/1.html
http://www.medterms.com/script/main/art.asp?articlekey=6591
International Union of Biochemistry and Molecular Biology



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Note added at 2 hrs 41 mins (2004-11-27 20:20:17 GMT)
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http://www.iubmb.unibe.ch/
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4 KudoZ points awarded for this answer. Comment: "many thanks to all, especially Elena. I'll go for the extra info which had not occurred to me. "
+2
3 mins

aspartate aminotransferase called also aspartate transaminase

according to Merriam Webster's Medical Desk Dictionary

aspartate aminotransferase
n :  an enzyme promoting transfer of an amino group from glutamic acid to oxaloacetic acid and which when present in abnormally high levels in the blood is a diagnostic indication of myocardial infarction or liver disease —called also aspartate transaminase, glutamic-oxaloacetic transaminase

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Note added at 10 mins (2004-11-27 17:49:38 GMT)
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and according to Dorland\'s Medical Dictionary

aspartate aminotransferase (as·par·tate ami·no·trans·fer·ase) aspartate transaminase.

aspartate transaminase (as·par·tate trans·am·i·nase) an enzyme of the transferase class that catalyzes the reversible transfer of an amino group from aspartate to a-ketoglutarate to form glutamate and oxaloacetate, with pyridoxal phosphate required as a cofactor. The enzyme is present in most eukaryotic cells, occurring as distinct isozymes in mitochondria and cytosol. Both isozymes participate in the malate-aspartate shuttle, and in the liver the reaction transfers excess metabolic nitrogen into aspartate for disposal via the urea cycle. The serum level of aspartate transaminase (SGOT) and that of other transaminases are frequently elevated in a variety of disorders causing tissue damage (e.g., myocardial infarction).
Abbreviated AST and ASAT.
Called also aspartate aminotransferase and glutamic-oxaloacetic transaminase (GOT).



Peer comment(s):

agree Sven Petersson
4 mins
agree Saleh Chowdhury, Ph.D.
9 hrs
Something went wrong...
+1
1 hr

aspartate aminotransferase

Hi Mbatrad,

I'd update the enzyme name. As you know, it was formerly called "GOT"= glutamate-oxaloacetate transaminase, was then called "AST= aspartate transaminase" but lately it's referred to as "AST= aspartate aminotransferase".

The word "transaminase(s)" to refer to the AST is still used when both AST and ASL are mentioned as a group (see example below).

Good luck,

Elena


a·mi·no·trans·fer·ase (-mn-trnsf-rs, -rz, m-n-)
n.

Any of various enzymes that catalyze the transfer of an amino group between an alpha-amino acid and usually a specific carbon on a keto acid. Also called aminopherase, transaminase.

http://dictionary.reference.com/search?q=aminotransferase&r=...


His LFT remained normal during January 2000, but his serum transaminases were found elevated on February 2000 ** (aspartate aminotransferase [AST] ** 206, alanine aminotransferase [ALT] 266). A liver biopsy then showed no evidence of TB or cytomegalovirus disease. The patient continued to have stable elevation of his ** serum AST ** and ALT until late March 2000 when a repeat liver biopsy showed caseating granuloma. The patient was started on anti-TB medications, with which he was compliant. By mid-May 2000 he was doing well, with significant reduction in his ** transaminase levels (AST 72, ALT 79) **

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&d...



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Note added at 1 hr 56 mins (2004-11-27 19:35:36 GMT)
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:::::::: Sorry about extra-floating the page -- it\'s probably my browser, Mozilla Firefox....
Peer comment(s):

agree Saleh Chowdhury, Ph.D.
7 hrs
Thanks, Saleh
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