Cumulative Risk Assessment - European Commission
https://ec.europa.eu › plants › maximum-residue-levels
... toxic effects in tissues, organs and physiological systems can produce joint, cumulative toxicity – even if they do not have similar modes of action.

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Note added at 47 mins (2022-06-20 11:16:39 GMT)
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A Case of Tacrolimus Maculopathy - MDPI
https://www.mdpi.com › pdf
PDF
by M Santarelli · 2022 — This finding may raise the hypothesis that Tacrolimus accumulates in the tissues with consequent cumulative dose toxicity over time. Most of the ...

Envarsus, INN-tacrolimus - European Medicines Agency |
https://www.ema.europa.eu › assessment-report
PDF
22 May 2014 — practice, tacrolimus dose adjustments are required based on ... difference between treatment groups in the cumulative incidence of freedom ...

Tacrolimus - edren.org
https://edren.org › handbook › immunosuppressive-drugs
25 Sept 2020 — Tacrolimus (Prograf /Advagraf /Adoport); Current indication; Dosage ... Interactions due to cumulative toxicity/synergistic effects:.

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Note added at 48 mins (2022-06-20 11:17:45 GMT)
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Cumulative toxicity tool and adverse drug reactions (ADR)
https://managemeds.scot.nhs.uk › principles › cumulati...
Cumulative toxicity tool and adverse drug reactions (ADR) ... It identifies where an ADR may be due to a cumulative effect. Generally, the shaded areas ...

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Note added at 52 mins (2022-06-20 11:21:48 GMT)
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Rituximab for the treatment of ANCA-associated vasculitis in ...
https://www.england.nhs.uk › a13-ritux-anca-vascul
PDF
treatment is likely to produce cumulative toxicity and a poorer response to ... were found to be of equal efficacy, with no difference in the duration of B ...