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split across
has gaps for all the ports
May 17, 2014 19:58
9 yrs ago
English term

compared with

English to Chinese Medical Other
The exposure multiples of AAA at the highest dose level in the rat and dog were approximately up to 3-fold and 1.8-fold, compared with AUC0-24h at 300 mg bid dose level in patients with BBB in the clinical phase I study。

是单纯的比较，还是COMPARABLE即“相当”的意思？如果是前者，到底前半句的哪个VARIABLE和后半句的哪个VARIABLE相比？
Proposed translations (Chinese)
3 比较
4 +1 与…相比
4 与。。。相比；或比较。。。，；
4 曝光倍数

Discussion

lyrebird06 May 25, 2014:
这个问题有点迷糊，最后是谁和谁比， BBB到底是指代病还是药，能贴出最后的翻译答案吗
jyuan_us (asker) May 25, 2014:
Thank you all. I think Bin's answer combined with his discussion entry is closest to the meaning in the source.
jyuan_us (asker) May 20, 2014:
I THINK Jina的理解也是对的 但是这个词组并未出现在300 mg bid dose level in patients with BBB那个分句中，所以原文有一定程度的模糊性，我计划让译文保持这种迷糊性，也就是用这种结构：“与。。。。相比，当大鼠和犬给予最高剂量时，其暴露倍数分别是前者的X和Y倍”。 在继续想措词
Bin Xue May 18, 2014:
那我理解错误了，是疾病的话，就是都是用AAA的药，那是说动物在最高级组暴露倍数“相当于”那些BBB成人病患的3倍和1.8倍？ http://www.docin.com/p-757066577.html 你看看这个的45页是不是对你的理解有帮助。
jyuan_us (asker) May 18, 2014:
exposure multiple暴露倍数 文章中没有上下文告诉我们the highest dose level的具体数字。
jyuan_us (asker) May 18, 2014:
When posting it, I used BBB to replace a disease for confidentiality reasons. BBB病人，大鼠和犬的用药应该都是AAA。Sorry for not being clear enough.

Proposed translations

12 hrs
Selected

比较

个人的理解是比较，比的是exposure
是关于毒性测试的吗

试译：与临床I期试验中成人患者服用的BBB (按AUC0-24（血药浓度）达300mg时)相比，当鼠给予AAA最大剂量时，其暴露量大约多达BBB的3倍。当狗给予本品最大剂量时，其暴露量大约多达BBB的1.8倍。

Reference:

http://wapbaike.baidu.com/subview/5262608/5292309.htm?uid=bk_1335906272_458&pu=sl%401%2Cpw%401000%2Csz%40224_220%2Cpd%401%2Cfz%402%2Clp%401%

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4 KudoZ points awarded for this answer.
+1
2 hrs

与…相比

前半句的 AAA at the highest dose level in the rat and dog
和后半句的 (AAA) at 300 mg bid dose level in patients with BBB 相比

前者和后者相比的 exposure multiple (based on AUC0-24H) 大约有 3倍(in rat)和1.8倍(in dog).

see reference
Reference:

http://books.google.ca/books?id=C0nzGNCHhL8C&pg=PA62&lpg=PA62&ots=1Sbmt3uu01&focus=viewport&dq=%22+exposure+multiple%22&output=html_text

http://pubs.acs.org/doi/abs/10.1021/tx100363k

Peer comment(s):
agree Jing Li
18 hrs
thanks
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16 hrs

与。。。相比；或比较。。。，；

但不是‘相当’。 ‘相当’应译成‘comparable'.

仅供参考。
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1 day 12 hrs

曝光倍数

The exposure multiples of AAA at the highest dose level in the rat and dog were approximately up to 3-fold and 1.8-fold, compared with AUC0-24h at 300 mg bid dose level in patients with BBB in the clinical phase I study。
在最高剂量水平下 采用AAA的rat和dog的曝光倍数是患BBB疾病患者在300 mg剂量水平下采用AUC0-24h的曝光倍数的多少倍

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Note added at 1 day12 hrs (2014-05-19 08:56:22 GMT)
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AAA 与AUC0-24h应该是属于某类显影剂吧，反应是某一类物质

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Note added at 2 days11 hrs (2014-05-20 07:20:23 GMT)
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总之比的是exposure multiples，至于是曝光还暴露，得看全文

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Note added at 2 days15 hrs (2014-05-20 11:24:14 GMT)
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生殖毒性：尚未进行本品对生育力影响的研究，但大鼠长期给予本品剂量大于或等于1mg/kg/日(其血浆Cssmax和AUC0-24h分别比绝经后健康人在推荐剂量下的高19倍和9倍)时
剂量水平相应的外推平均AUC0-24h为1448ng.h/ml(相当于成从患者最大暴量的至少63倍)。在剂量水平达到110mg/㎡/天，对生殖能力没有影响

那得看看AAA（指代的什么药物），如果也有毒性，可能就是最大暴露量，

很有可能原文省略了exposure multiple，

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Note added at 2 days15 hrs (2014-05-20 11:34:01 GMT)
--------------------------------------------------

AUC0,24H stands for areas under the curve from 0 to 24 h
最后我也认为Jina的理解是对的，主要涉及AUC0,24H
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